[1]邓思,王海琪,白曼利,等.法夫酵母类胡萝卜素提取物对肝损伤的保护作用[J].集美大学学报(自然版),2018,23(6):421-428.
 DENG Si,WANG Haiqi,BAI Manli,et al.The Protective Effects of Carotenoids Extract from Phaffia rhodozyma on Hepatic Injury[J].Journal of Jimei University,2018,23(6):421-428.
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法夫酵母类胡萝卜素提取物对肝损伤的保护作用()
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《集美大学学报(自然版)》[ISSN:1007-7405/CN:35-1186/N]

卷:
第23卷
期数:
2018年第6期
页码:
421-428
栏目:
水产、食品与生物技术
出版日期:
2018-11-28

文章信息/Info

Title:
The Protective Effects of Carotenoids Extract from Phaffia rhodozyma on Hepatic Injury
作者:
邓思1王海琪1白曼利1杨远帆1234黄高凌1234杜希萍1234倪辉1234
(1.集美大学食品与生物工程学院,福建 厦门 361021;2.福建省食品微生物与酶工程重点实验室,福建 厦门 361021;3.厦门市食品与生物工程技术研究中心,福建 厦门 361021;4.厦门南方海洋研究中心海藻资源化利用与深加工重点实验室,福建 厦门 361021)
Author(s):
DENG Si1WANG Haiqi1BAI Manli1YANG Yuanfan1234HUANG Gaoling1234DU Xiping1234NI Hui1234
(1.College of Food and Biological Engineering,Jimei University,Xiamen 361021,China;2.Fujian Provincial Key Laboratory of Food Microbiology and Enzyme Engineering,Xiamen 361021,China;3.Research Center of Food Biotechnology of Xiamen City,Xiamen 361021,China;4.Key Laboratory of Systemic Utilization and Indepth Processing of Economic Seaweed,Xiamen Southern Ocean Technology Center of China,Xiamen 361021,China)
关键词:
法夫酵母类胡萝卜素四氯化碳化学性肝损伤病理学检
Keywords:
Phaffia rhodozyma carotenoidsCCl4chemical hepatic injurypathological examination
文献标志码:
A
摘要:
为了明确法夫酵母(Phaffia rhodozyma)类胡萝卜素提取物对化学性肝损伤大鼠丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)肝细胞坏死程度的影响,建立CCl4诱导大鼠化学性肝损伤模型,将60只大鼠随机分成6组,分别是正常组,模型组,联苯双酯组,低、中、高剂量组(受试样剂量分别为0.187 5、0.375、0.75 g/kg),检测大鼠血清中ALT、AST活性,并观察肝脏细胞的病理损伤情况。结果显示,法夫酵母类胡萝卜素高剂量组大鼠血清ALT与模型组比较显著降低(P<0.05),受试样品不同剂量组大鼠的肝细胞病变均有不同程度的减轻。表明,法夫酵母类胡萝卜素提取物对大鼠化学性肝损伤有辅助保护作用。
Abstract:
The protective effects of carotenoids extract from Phaffia rhodozyma on chemical-induced liver injuries in rats were determined.Sixty rats were randomly divided into six groups:normal group,model group,bifendate group and test groups treated with low dose (0.187 5 g/kg),medium dose (0.375 g/kg) and high dose (0.75 g/kg) of carotenoids extract.Except the normal group,other groups were liver­injured by carbon tetrachloride (CCl4).The activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum were detected,and the pathologic changes of liver were observed.Compared with model group,the ALT activity in rat serum of the high does group carotenoids extract significantly decreased (P<0.05).The test sample with different dose groups could reduce the hepatic necrosis in chemical­induced liver injuries by CCl4 in rats.These results suggested that the carotenoids extract from P.rhodozyma had auxiliary effects in protecting chemical-induced liver injuries in rats.

相似文献/References:

[1]陈丽娜,朱艳冰,倪辉,等.法夫酵母整合型表达载体的构建[J].集美大学学报(自然版),2014,19(3):185.
 CHEN Li-na,ZHU Yan-bing,NI Hui,et al.Construction of Integrative Expression Vectors for Phaffia rhodozyma[J].Journal of Jimei University,2014,19(6):185.
[2]付爽,沈宁燕,倪辉,等.乙醇补料对法夫酵母发酵产虾青素的促进效果[J].集美大学学报(自然版),2017,22(4):20.
 FU Shuang,SHEN Ningyan,NI Hui,et al.Promotion Effect of Ethanol on Astaxanthin Synthesis During Fed-batch by Phaffia rhodozyma[J].Journal of Jimei University,2017,22(6):20.

更新日期/Last Update: 2019-01-18