联合有氧运动对高脂血症大鼠影响-《体育科学研究》

文章信息/Info

Title:: Effects of Compound Chinese Medicine Prescription Combined with Aerobic Exercise on HO-1/CO System and Skeletal Muscle Lipid Metabolism in hyperlipemia Rats

Author(s):: TIAN Zhen-xiang1; GENG Qing-qing2; XU De-gang1; (1.Zaozhuang University,Zaozhuang 277160,China;2.Shandong Sport University,Jinan 250001,China)

Keywords:: Traditional Chinese medicine (TCM); HO-1; endogenous CO; aerobic exercise; hyperlipemia

摘要:: 探讨复方中药制剂联合运动对高脂血症大鼠不同组织HO-1/CO系统的影响。将47只雄性 SD 大鼠分为对照组、复方中药制剂组、单纯运动组、运动+中药组。复方中药制剂灌胃，运动干预为跑台运动。测定标本中大鼠骨骼肌和心肌不同组织中的血红素氧合酶1（HO-1）水平、CO含量、血清T-AOC含量、骨骼肌肌内甘油三酯含量、激素敏感脂肪酶（HSL）和脂蛋白脂酶（LPL）活性。研究结果：复方中药制剂和有氧运动均可以不同程度地提高机体的总抗氧化能力、HO-1/ CO系统水平以及骨骼肌脂代谢水平，高脂血症大鼠服用复方中药制剂的同时坚持有氧运动的效果更显著，有氧运动对不同组织 HO/ CO 的刺激反应具有选择性，骨骼肌对运动的应激反应更为显著。

Abstract:: To explore the effect of combined exercise and compound Chinese medicine prescription on ho-1 /CO system in hyperlipidemia rats.47 male SD rats were divided into control group，compound Chinese medicine prescription group，exercise group and exercise + Chinese medicine group.Compound Chinese medicine prescription was intragastric administration，sports intervention was running on platform.The levels of heme oxygenase 1 (ho-1)，CO，serum t-aoc and skeletal muscle triglyceride，hormonesensitive lipase (HSL) and lipoprotein lipase (LPL) in skeletal muscle and myocardium were measured.The compound Chinese medicine prescription and aerobic exercise can improve the total antioxidant capacity，HO-1 / CO system level，and skeletal muscle fat metabolism.Compound Chinese medicine prescription combined with exercise showed a more significant effect.Skeletal muscle responds more manifestly to exercise stress.