|本期目录/Table of Contents|

[1]蔡科,刘一平.运动介导低氧诱导间充质干细胞在糖尿病足血管新生中的作用[J].体育科学研究,2023,27(2):67-73.
　CAI Ke,LIU Yi-ping.The Role of Exercise Mediates hypoxia-Induced Mesenchymal Stem Cells in Angiogenesis of Diabetic Foot[J].sports science research,2023,27(2):67-73.
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运动介导低氧诱导间充质干细胞在糖尿病足血管新生中的作用(PDF)
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《体育科学研究》[ISSN:1006-6977/CN:61-1281/TN]

卷:
27
期数:
2023年2期
页码:
67-73
栏目:
体育生物科学
出版日期:
2023-05-09

文章信息/Info

Title:
The Role of Exercise Mediates hypoxia-Induced Mesenchymal Stem Cells in Angiogenesis of Diabetic Foot
作者:
蔡科; 刘一平
（福建师范大学体育科学学院运动与健康福建省高校重点实验室，福建 福州 350117）
Author(s):
CAI Ke; LIU Yi-ping
（School of Physical Education and Sport Sciences，Fujian Normal University，Provincial University Key Laboratory of Sport and Health Science，Fuzhou 350117, China）
关键词:
运动; 血管新生; 低氧诱导因子-1α; 间充质干细胞; 糖尿病足
Keywords:
exercise;  angiogenesis;  hypoxia inducible factor1α;  mesenchymal stem cells;  diabetic foot
分类号:
-
DOI:
-
文献标志码:
A
摘要:
糖尿病足（diabetic foot，DF）作为糖尿病常见的并发症，目前尚未发现理想的治疗手段，且糖尿病发展为DF的发病机制尚未厘清，但有效的干预措施可以改善糖尿病血管病变的发生、发展和降低DF发生风险。因此，探究DF新的发病机制对丰富其治疗手段具有重要的意义。间充质干细胞（mesenchymal stem cells，MSCs）成为DF研究的新兴热点，运动介导低氧诱导MSCs促进DF血管新生成为运动干预DF可能的关键机制之一。回顾运动介导机体在低氧状态下的相关研究，对低氧诱导因子-1α（hypoxia inducible factor-1α，HIF-1α）的依赖途径上调血管内皮生长因子（vascular endothelial growth factor ,VEGF）表达从而增强MSCs促血管生成活性及运动干预机制进行了综述，提出运动介导低氧诱导MSCs分化可能成为DF有效预防、延缓和治疗的一种新途径。科学运动促进MSCs分泌促血管生长因子和释放外分泌体调控血管新生从而缓解DF缺血、缺氧可能是防治DF不同病程的有效策略。
Abstract:
As a common complication of diabetes, diabetic foot (DF) is not yet an ideal treatment, and the pathogenesis of DF is yet to be clarified. However, effective interventions will improve the occurrence and development of diabetic vascular diseases and reduce the risk of DF. Therefore, it is of great significance to study the new pathogenesis of DF to enrich its treatment. Mesenchymal stem cells (MSCs) have become a new hotspot in DF research. Exercise’ mediated hypoxia induces MSCs to promote DF angiogenesis, which is one of the possible key mechanisms of exercise intervention in DF. This paper reviewed the relevant studies on the exercise’ mediated body in a hypoxia state, and reviewed the mechanism of exercise intervention by upregulating the expression of vascular endothelial growth factor (VEGF) through hypoxia inducible factor-1α (HIF-1α) dependent pathway to enhance the activity of MSCs in promoting angiogenesis. It is suggested that exercise-mediated hypoxia induced MSCs differentiation may be a new way to effectively prevent, delay and/or treat DF development. Scientific exercise can promote the secretion of angiogenic growth factor and basic fibroblast growth factor by MSCs and release exocrine to regulate angiogenesis and relieve DF ischemia and hypoxia, which may be an effective strategy to prevent and treat DF with a different course of the disease.

参考文献/References:

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备注/Memo

备注/Memo:
更新日期/Last Update: 2023-07-04