|本期目录/Table of Contents|

[1]户晶晶,王瑞芳,王力,等.轮型钼簇对α-葡萄糖苷酶的抑制作用[J].集美大学学报(自然科学版),2020,25(4):265-271.
　HU Jingjing,WANG Ruifang,WANG Li,et al.Study on the Inhibition of -Glucosidase by Wheel-type Molybdenum Clusters[J].Journal of Jimei University,2020,25(4):265-271.
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《集美大学学报（自然科学版）》[ISSN:1007-7405/CN:35-1186/N]

卷:
第25卷
期数:
2020年第4期
页码:
265-271
栏目:
水产、食品与生物工程
出版日期:
2020-07-28

文章信息/Info

Title:
Study on the Inhibition of -Glucosidase by Wheel-type Molybdenum Clusters
作者:
户晶晶; 王瑞芳; 王力; 丁小梅; 李月
(集美大学食品与生物工程学院,福建 厦门 361021 )
Author(s):
HU Jingjing; WANG Ruifang; WANG Li; DING Xiaomei; LI Yue
(College of Food and Biological Engineering,Jimei University,Xiamen 361021,China)
关键词:
α-葡萄糖苷酶; 轮型钼簇; 抑制剂; 酶动力学
Keywords:
α-glucosidase; wheel-type molybdenum clusters; inhibitors; enzyme kinetics
分类号:
-
DOI:
-
文献标志码:
-
摘要:
通过酶动力学方法考察了轮型钼簇(Mo36、Mo57Mn6、Mo57V6、Mo57Fe6）对α-葡萄糖苷酶的抑制效果、抑制机理和抑制类型。结果表明：Mo36、Mo57Mn6、Mo57V6、Mo57Fe6对α-葡萄糖苷酶均有较好的抑制效果，其中Mo57Fe6对α-葡萄糖苷酶的抑制效果最好，其IC50=(0.025 9±0.000 328)mmol/L；Mo36对α-葡萄糖苷酶的抑制作用为可逆竞争型抑制，Mo57Mn6、Mo57V6、Mo57Fe6的抑制作用为可逆混合型抑制。
Abstract:
The inhibitory effect,inhibition mechanism and inhibition type of α-glucosidase by wheel-type molybdenum clusters(Mo36,Mo57Mn6,Mo57V6,Mo57Fe6) were studied by enzyme kinetics.The results showed that Mo36,Mo57Mn6,Mo57V6 and Mo57Fe6 had good inhibitory effects on α-glucosidase.The half inhibition rate of Mo57Fe6 with the best inhibitory effect on αglucosidase was (0.025 9±0.000 328) mmol/L.The inhibitory types of Mo36 on α-glucosidase showed reversible competitive inhibition,and the inhibitory types of Mo57Mn6,Mo57V6 and Mo57Fe6 on α-glucosidase were reversible mixed inhibition.

参考文献/References:

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相似文献/References:

[1]王瑞芳,帅蝶,孙乐常,等.多金属氧酸盐类α-葡萄糖苷酶抑制剂的研究进展[J].集美大学学报(自然科学版),2023,28(2):126.
　WANG Ruifang,SHUAI Die,SUN Lechang,et al.Research Progress of Polyoxometalates as α-Glucosidase Inhibitors[J].Journal of Jimei University,2023,28(4):126.

备注/Memo

备注/Memo:
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更新日期/Last Update: 2020-09-16